Eco-friendly Synthesis of Gold Nanoparticles from Antarctic Bacteria for Therapeutic Use
- by Team ABLE - 30 Jun, 2020
The National Centre for Polar and Ocean Research (NCPOR) and the Goa University (GU) have successfully synthesized gold nanoparticles (GNPs) using psychrotolerant Antarctic bacteria through a non-toxic, low-cost, and eco-friendly way.
Led by Dr. Kirti Ranjan Das of Environmental Impact Assessment Cell of NCPOR, the research team comprised Dr. Anoop Kumar Tiwari, Senior Scientist at NCPOR, and Prof. Savita Kerkar of the Dept. of Biotechnology, Goa University. Their research paper has been recently published in the Journal of Preparative Biochemistry & Biotechnology.
Through a study, NCPOR and GU have established that 20-30-nm-sized spherical-shaped GNPs could be synthesized in a controlled environment. These GNPs can be used as a composite therapeutic agent clinical trials, especially in anti-cancer, anti-viral, anti-diabetic, and cholesterol-lowering drugs.
The NCPOR-GU study revealed genotoxic effect of GNPs on a sulphate reducing bacteria (SRB). The GNPs displayed enough anti-bacterial properties by inhibiting the growth of SRB and its sulphide production by damaging the genetic information of the DNA of the bacterial cell. Genotoxicity describes the property of a chemical agent that is capable of damaging the genetic information of DNA and thus causing mutation of the cell, which can lead to cancer.
Nanoparticles (NPs) have wide variety of potential applications in the fields of biomedical, optical and electronics research. Metallic NPs have been efficiently exploited for biomedical applications and among them GNPs are found to be effective in biomedical research.
NCPOR and GU have resorted to environmentally acceptable green chemistry procedures to reduce gold ion to GNPs using psychrotolerant Antarctic bacteria. Moreover, they did not have to use synthetic chemical additives as stabilizing or reducing agents. Use of psychrotolerant Antarctic bacteria is found to have special advantages like mild reaction condition to reduce gold ion to Gold Nanoparticles (GNPs) with a good dispersion capability.
Through a study, NCPOR and GU have established that 20-30-nm-sized spherical-shaped GNPs could be synthesized in a controlled environment.