iView Therapeutics Inc. has announced that the first patient has been dosed in the Phase 2 IVIEW-1201-01-AIC clinical trial program assessing the efficacy of IVIEW-1201 in patients (age ≥15 years) with Acute Adenoviral Conjunctivitis. First subject was dosed on 19 Dec inIndiaat Disha Eye Hospital Pvt. Ltd.Kolkataunder this Phase II Clinical trial program.This study is planned in US,IndiaandChinasimultaneously.

“Acute Infectious Conjunctivitis is the most common and contagious ocular infections globally. There is no approved treatment for acute viral conjunctivitis, which represents a large unmet medical need in ophthalmology,” saidBo Liang, Chairman & President, iView Therapeutic Inc. “IVIEW-1201 is a broad-spectrum antiseptic gel forming ophthalmic solution which is potentially effective against all infectious pathogens including bacteria, mycobacteria,fungus and virus. The initiation of the global Phase 2 clinical trial program is an important milestone as we seek to provide an effective treatment option for AVC patients.”

Acute infectious conjunctivitis is a leading cause of ocular morbidity, epidemic eye infection, lost productivity, patient discomfort and in some cases permanent visual compromise. Viral conjunctivitis is very contagious and can often lead to long term ocular morbidity but there is currently no FDA-approved treatment.

The objective of this study is to assess the efficacy of IVIEW-1201 as a first-line treatment for ocular infection in the setting of an acute adenoviral conjunctivitis infection.

"As we have successfully dosed our first patient in India, we are excited and looking forward to have more patients get treated and be benefit from this study," said leading PI, Dr. Virender Sangwan, Director of Innovation at Dr. Shroff Charity Eye Hospital.

IVIEW-1201 is a novel in-situ gel forming ophthalmic solution with in-vitro efficacy against many bacteria, yeasts, fungi and human adenovirus. In preclinical evaluation, it demonstrated antimicrobial efficacy on contact with ocular isolates ofPseudomonas aeuroginosa,and Methicillin Resistant- Staphylococcus Aureus (MRSA)andCandida parapsilosis. In a cytopathic effect study with human AE549 cells, IVIEW-1201 demonstrated complete inactivation of Human Adenovirus Type 5.

Acute infectious conjunctivitis is a leading cause of ocular morbidity, epidemic eye infection, lost productivity, patient discomfort and in some cases permanent visual compromise.